Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 4/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.47 |
| ▸ | TTR | P02766 | 2/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.47 |
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.47 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.47 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11122074 | 0.86 | CA2 (0.49) | CXCL8CA2PTGS2PTGS1TTR | |
| SCHEMBL5778304 | 0.84 | PTGS1 (0.47) | CA2PTGS2PTGS1 | |
| SCHEMBL11125379 | 0.82 | PTGS1 (0.46) | CXCL8CA2PTGS2PTGS1 | |
| SCHEMBL514554 | 0.82 | CA2 (0.54) | CA2PTGS2PTGS1 | |
| SCHEMBL7888388 | 0.79 | PTGS2 (0.54) | CXCL8PTGS2AKR1B1PTGS1TTR | |
| SCHEMBL9571369 | 0.79 | CA2 (0.54) | CA2PTGS2PTGS1 | |
| SCHEMBL11124220 | 0.78 | CA2 (0.42) | CXCL8CA2PTGS2PTGS1AGTR2 | |
| SCHEMBL11124223 | 0.78 | KMT2A (0.46) | CA2PTGS2PTGS1 | |
| SCHEMBL5205026 | 0.78 | ALDH1A1 (0.58) | CXCL8PTGS2PTGS1TTRNR1H4 | |
| SCHEMBL11119042 | 0.77 | PTGS1 (0.45) | CA2PTGS2PTGS1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1652839-A2 | Drug efflux pump inhibitor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-1227084-B1 | DRUG DISCHARGE PUMP INHIBITORS | TRINE PHARMACEUTICALS INC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1227084-A1 | DRUG DISCHARGE PUMP INHIBITORS | Microcide Pharmaceuticals, Inc. (US) | 2002-07-31 | — | — | EP | disclosed |
| EP-0038636-B1 | SULFONAMIDE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND THEIR PRODUCTION AND USE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1984-01-11 | — | — | EP | disclosed |
| US-4321081-A | Ortho-(trifluoromethylsulfonamido)benzamides as herbicides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-03-23 | — | — | US | disclosed |
| EP-0038636-A2 | Sulfonamide derivatives, compositions containing them and their production and use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-10-28 | — | — | EP | disclosed |