Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 15/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777840 | 0.86 | TBXA2R (0.46) | PTGDR2TBXA2R | |
| SCHEMBL5775625 | 0.85 | S1PR1 (0.47) | S1PR1S1PR5S1PR4TBXA2RFFAR4 | |
| SCHEMBL5772689 | 0.84 | TBXA2R (0.39) | PTGDR2TBXA2R | |
| SCHEMBL5835082 | 0.82 | KDM4E (0.31) | — | |
| SCHEMBL5779554 | 0.82 | S1PR1 (0.43) | S1PR1S1PR5S1PR4TBXA2RFFAR4 | |
| SCHEMBL5776896 | 0.77 | TBXA2R (0.52) | PTGDR2TBXA2R | |
| SCHEMBL28537384 | 0.72 | S1PR1 (0.52) | S1PR1S1PR5S1PR4FFAR4 | |
| SCHEMBL5777130 | 0.71 | S1PR1 (0.44) | S1PR1S1PR5S1PR4TBXA2RFFAR4 | |
| SCHEMBL5776224 | 0.70 | TBXA2R (0.42) | S1PR1S1PR5S1PR4TBXA2R | |
| SCHEMBL5775673 | 0.70 | S1PR1 (0.42) | S1PR1S1PR5S1PR4PTGDR2TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395590-B1 | DIHYDROPYRROLO¬1,2-A|INDOLE AND TETRAHYDROPYRIDO¬1,2-A|INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA INC (CA) | 2006-09-27 | — | — | EP | disclosed |