Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 6/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 3/20 | 0.31 |
| ▸ | HTR3A | P46098 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777307 | 0.78 | TBXA2R (0.32) | TBXA2RPTGDR2MEN1KMT2AHTR1A | |
| SCHEMBL5773536 | 0.72 | TBXA2R (0.56) | TBXA2RPTGDR2HTR1AAKR1B1 | |
| SCHEMBL5778173 | 0.68 | TBXA2R (0.50) | TBXA2RPTGDR2AKR1B1 | |
| SCHEMBL5776538 | 0.66 | TBXA2R (0.39) | TBXA2RPTGDR2AKR1B1 | |
| SCHEMBL21984840 | 0.57 | MEN1 (0.46) | MEN1KMT2AHTR1AHTR3ACYP1A2 | |
| SCHEMBL3546610 | 0.55 | MEN1 (0.47) | PTGDR2MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL3541411 | 0.55 | MEN1 (0.47) | TBXA2RPTGDR2MEN1KMT2ACYP1A2 | |
| SCHEMBL9476350 | 0.53 | MAOA (0.64) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL481976 | 0.53 | MAOA (0.64) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9475224 | 0.53 | MAOA (0.64) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395590-B1 | DIHYDROPYRROLO¬1,2-A|INDOLE AND TETRAHYDROPYRIDO¬1,2-A|INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA INC (CA) | 2006-09-27 | — | — | EP | disclosed |