Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 14/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 2/20 | 0.32 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773536 | 0.81 | TBXA2R (0.56) | TBXA2RPTGDR2AKR1B1PDE2APTGDR | |
| SCHEMBL5778175 | 0.80 | TBXA2R (0.49) | TBXA2RPTGDR2AKR1B1PDE2APTGDR | |
| SCHEMBL6729120 | 0.75 | TBXA2R (0.86) | TBXA2RPTGDR2PDE2APTGDR | |
| SCHEMBL5777733 | 0.70 | TBXA2R (0.42) | TBXA2RPTGDR2 | |
| SCHEMBL5777302 | 0.68 | TBXA2R (0.33) | TBXA2RPTGDR2AKR1B1 | |
| SCHEMBL5776535 | 0.68 | TBXA2R (0.39) | TBXA2RPTGDR2 | |
| SCHEMBL5840675 | 0.67 | TBXA2R (1.00) | TBXA2RPTGDR2PDE2APTGDR | |
| SCHEMBL4548360 | 0.66 | TBXA2R (0.90) | TBXA2RPTGDR2PDE2APTGDR | |
| SCHEMBL13317737 | 0.66 | TBXA2R (0.90) | TBXA2RPTGDR2PDE2APTGDR | |
| SCHEMBL5778034 | 0.62 | TBXA2R (0.43) | TBXA2RPDE2APTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395590-B1 | DIHYDROPYRROLO¬1,2-A|INDOLE AND TETRAHYDROPYRIDO¬1,2-A|INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA INC (CA) | 2006-09-27 | — | — | EP | disclosed |