Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5776657 | 0.91 | MAPT (0.42) | HDAC4HDAC1HDAC6MAPTHPGD | |
| Trifluoroacetic Acid SCHEMBL5775794 | 0.90 | KCNH2 (0.38) | ACKR3KCNH2MAPTHPGDTSHR | |
| Trifluoroacetic Acid SCHEMBL5774893 | 0.87 | GAA (0.47) | ACKR3KCNH2HDAC4HDAC6MAPT | |
| Trifluoroacetic Acid SCHEMBL5774082 | 0.86 | ACKR3 (0.42) | ACKR3KCNH2HDAC4HDAC1HDAC6 | |
| Trifluoroacetic Acid SCHEMBL5775527 | 0.86 | L3MBTL1 (0.36) | HDAC4HPGDTSHRHTTLMNA | |
| Trifluoroacetic Acid SCHEMBL5777271 | 0.86 | GAA (0.37) | ACKR3KCNH2HDAC6MAPTMAPK1 | |
| Trifluoroacetic Acid SCHEMBL5774844 | 0.84 | HDAC4 (0.40) | KCNH2HDAC4HDAC1HDAC6HPGD | |
| Trifluoroacetic Acid SCHEMBL5770496 | 0.84 | HDAC4 (0.36) | HDAC4TSHRALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5773568 | 0.83 | EPHX2 (0.52) | KCNH2HPGD | |
| Trifluoroacetic Acid SCHEMBL5774671 | 0.83 | MAPT (0.54) | KCNH2MAPTHPGDTSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | ACKR3 542/4885KCNH2 1149/4885HDAC4 434/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | ACKR3 1331/4885KCNH2 834/4885HDAC4 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.