Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 8/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | PTGFR | P43088 | 1/20 | 0.32 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | PTGIR | P43119 | 1/20 | 0.32 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5778038 | 0.80 | TBXA2R (0.42) | TBXA2RDRD2HTR1AHTR2ADRD3 | |
| SCHEMBL6727090 | 0.66 | TBXA2R (0.75) | TBXA2RPTGER1PTGER4PTGFRPTGER3 | |
| SCHEMBL5777733 | 0.65 | TBXA2R (0.42) | TBXA2RDRD2HTR1A | |
| SCHEMBL6579205 | 0.61 | PTGDR (0.55) | TBXA2RDRD3MAPTPTGER1PTGER4 | |
| SCHEMBL2135113 | 0.57 | TAAR1 (0.68) | IDO1 | |
| SCHEMBL12147413 | 0.56 | TAAR1 (0.50) | IDO1 | |
| SCHEMBL18550393 | 0.56 | TAAR1 (0.54) | HTR2AIDO1 | |
| SCHEMBL27891098 | 0.55 | TAAR1 (0.57) | DRD2IDO1 | |
| SCHEMBL14143081 | 0.54 | PSEN1 (0.51) | HTR2AMAPTHTR2C | |
| SCHEMBL10501653 | 0.53 | DRD2 (0.58) | DRD2HTR1AHTR2ADRD3TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395590-B1 | DIHYDROPYRROLO¬1,2-A|INDOLE AND TETRAHYDROPYRIDO¬1,2-A|INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA INC (CA) | 2006-09-27 | — | — | EP | disclosed |