Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5775498 | 0.78 | CYP1A2 (0.41) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL29957403 | 0.77 | ALDH1A1 (0.46) | HSD17B10KDM4EKCNJ1ALDH1A1ALDH1A3 | |
| SCHEMBL5777382 | 0.75 | SLC6A2 (0.33) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL5777383 | 0.75 | SLC6A2 (0.33) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL7563935 | 0.74 | NOS3 (0.51) | HSD17B10KDM4EKCNJ1ALDH1A1MEN1 | |
| SCHEMBL5776978 | 0.74 | PLAU (0.43) | HSD17B10KDM4EKCNJ1ALDH1A1ALDH1A3 | |
| SCHEMBL8484264 | 0.70 | CYP1A2 (0.40) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL4103388 | 0.69 | CYP1A2 (0.76) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL24528920 | 0.68 | KDM4E (0.59) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL16705718 | 0.67 | KDM4E (0.41) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276722-B1 | NAPHTHAMIDINE UROKINASE INHIBITORS | ABBOTT LAB (US) | 2006-03-08 | — | — | EP | disclosed |
| EP-1276722-A1 | NAPHTHAMIDINE UROKINASE INHIBITORS | Abbott Laboratories (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6504031-B1 | Enzyme inhibitor such as 6-(2-(1-isopropyl-1,2,3,4-tetrahydro -7-isoquinolinyl)ethenyl)-2-naphthalenecarboximidamide, used as angiogenesis inhibitors; antiarthritic, antiinflammatory and antitumor agents | ABBOTT LABORATORIES | 2003-01-07 | — | — | US | disclosed |
| US-6495562-B1 | SUCH AS 6-(2-(4,4-DIETHYL-1-ISOPROPYL-3,4-DIHYDRO-6-ISOQUINOLINYL)CYCLOPROPYL)-2 -NAPHTHALENECARBOXIMIDAMIDE | ABBOTT LABORATORIES | 2002-12-17 | — | — | US | disclosed |
| WO-2001081314-A1 | NAPHTHAMIDINE UROKINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2001-11-01 | — | — | WO | disclosed |