Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 3/20 | 0.51 |
| ▸ | NOS2 | P35228 | 3/20 | 0.51 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29957403 | 0.80 | ALDH1A1 (0.46) | NOS3NOS2KCNJ1ALDH1A1MEN1 | |
| SCHEMBL5776978 | 0.76 | PLAU (0.43) | NOS3NOS2KCNJ1ALDH1A1MEN1 | |
| SCHEMBL5778347 | 0.74 | CYP1A2 (0.39) | KCNJ1ALDH1A1MEN1GAAMAPT | |
| SCHEMBL8106265 | 0.70 | NOS3 (0.51) | NOS3NOS2ALDH1A1MEN1MAPT | |
| SCHEMBL7231960 | 0.69 | PBRM1 (0.55) | KCNJ1ALDH1A1MEN1GAAMAPT | |
| SCHEMBL30789182 | 0.69 | NOS3 (1.00) | NOS3NOS2ALDH1A1KDM4ETSHR | |
| SCHEMBL7454314 | 0.69 | NOS3 (1.00) | NOS3NOS2ALDH1A1KDM4ETSHR | |
| SCHEMBL24199473 | 0.68 | KCNJ1 (0.38) | KCNJ1ALDH1A1MEN1GAAMAPT | |
| SCHEMBL14024293 | 0.67 | MAOA (0.50) | KCNJ1ALDH1A1MEN1GAAMAPT | |
| SCHEMBL5776013 | 0.67 | PLAU (0.42) | KCNJ1ALDH1A1MEN1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020040144-A1 | 1-amino-7-isoquinoline derivatives as serine protease inhibitors | TULARIK LIMITED (GB) | 2002-04-04 | — | — | US | claimed |
| US-6262069-B1 | 1-amino-7-isoquinoline derivatives as serine protease inhibitors | PROTHERICS MOLECULAR DESIGN LIMITED (GB) | 2001-07-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020040144-A1 | 1-amino-7-isoquinoline derivatives as serine protease inhibitors | CTRL, HPN, CTSL | NOS3 2130/4885NOS2 2563/4885KCNJ1 4579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.