Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12484097 | 0.83 | P2RX7 (0.44) | METAP2SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL4481164 | 0.80 | SMN1; SMN2 (0.41) | METAP2SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL5598264 | 0.79 | RAB9A (0.54) | SMN1; SMN2HPGDNPC1RAB9ATAS1R3 | |
| SCHEMBL12484029 | 0.78 | P2RX7 (0.38) | METAP2SMN1; SMN2HPGDAKT1CNR2 | |
| SCHEMBL4468343 | 0.77 | SMN1; SMN2 (0.39) | METAP2SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL12483302 | 0.77 | MEN1 (0.46) | METAP2SMN1; SMN2HPGDKMT2AMEN1 | |
| SCHEMBL18835452 | 0.77 | HPGD (0.55) | SMN1; SMN2HPGDNPC1RAB9ACA12 | |
| SCHEMBL4473225 | 0.75 | NOTUM (0.40) | METAP2AKT1 | |
| SCHEMBL12483241 | 0.75 | FPR2 (0.40) | METAP2SMN1; SMN2HPGDAKT1PYGL | |
| SCHEMBL12483172 | 0.75 | GRM4 (0.41) | SMN1; SMN2NPC1RAB9AAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626962-A1 | BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | Pfizer Products Inc. (US) | 2006-02-22 | — | — | EP | disclosed |
| WO-2004099146-A1 | BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2004-11-18 | — | — | WO | disclosed |