Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.48 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.48 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PYGL | P06737 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5643173 | 0.84 | TAS1R3 (0.64) | RAB9ATDP1ALDH1A1ITGB1ITGA4 | |
| SCHEMBL5598411 | 0.82 | NPC1 (0.64) | RAB9ATDP1ALDH1A1HPGDMAPT | |
| SCHEMBL12484097 | 0.82 | P2RX7 (0.44) | RAB9ATDP1ALDH1A1P2RX7TAS1R3 | |
| SCHEMBL12483302 | 0.81 | MEN1 (0.46) | TDP1ITGB1ITGA4ITGB7HPGD | |
| SCHEMBL4481164 | 0.79 | SMN1; SMN2 (0.41) | RAB9ATDP1ALDH1A1P2RX7TAS1R3 | |
| SCHEMBL5779043 | 0.79 | METAP2 (0.41) | RAB9ATAS1R3TAS1R1HPGDSMN1; SMN2 | |
| SCHEMBL12482790 | 0.78 | PKM (0.40) | RAB9ATAS1R3TAS1R1HPGDTSHR | |
| SCHEMBL5598241 | 0.78 | RAB9A (0.53) | RAB9AALDH1A1TSHRLMNAMAPT | |
| SCHEMBL6171268 | 0.78 | RAB9A (0.53) | RAB9AALDH1A1TSHRLMNAMAPT | |
| SCHEMBL5598470 | 0.78 | RAB9A (0.53) | RAB9AALDH1A1TSHRLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763353-A1 | COMBINATION THERAPIES UTILIZING BENZAMIDE INHIBITORS OF THE P2X<sb>7</sb> RECEPTOR | Warner-Lambert Company LLC (US) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006003517-A1 | COMBINATION THERAPIES UTILIZING BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-12 | — | — | WO | disclosed |