Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 5/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777717 | 1.00 | MEN1 (0.57) | MEN1CYP1A2KMT2ALMNAHTT | |
| SCHEMBL5777721 | 1.00 | MEN1 (0.57) | MEN1CYP1A2KMT2ALMNAHTT | |
| SCHEMBL10902799 | 0.86 | MEN1 (0.58) | MEN1CYP1A2KMT2ALMNAHTT | |
| SCHEMBL11768010 | 0.83 | MEN1 (0.58) | MEN1CYP1A2KMT2ALMNAHTT | |
| SCHEMBL14198908 | 0.80 | CYP1A2 (0.64) | MEN1CYP1A2KMT2ALMNAHTT | |
| SCHEMBL11551 | 0.79 | MEN1 (0.62) | MEN1CYP1A2KMT2ALMNAHTT | |
| SCHEMBL11122536 | 0.78 | LMNA (0.58) | MEN1CYP1A2KMT2ALMNAHTT | |
| SCHEMBL961132 | 0.77 | LMNA (0.64) | MEN1CYP1A2KMT2ALMNAHTT | |
| SCHEMBL16371336 | 0.75 | CYP1A2 (0.61) | MEN1CYP1A2KMT2ALMNAHTT | |
| SCHEMBL30930111 | 0.75 | CYP1A2 (0.61) | MEN1CYP1A2KMT2ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322621-B1 | NEW BENZIMIDAZOLONE DERIVATIVES DISPLAYING AFFINITY AT THE SEROTONIN AND DOPAMINE RECEPTORS | BOEHRINGER INGELHEIM PHARMA (DE) | 2006-10-04 | — | — | EP | disclosed |
| EP-1322621-A1 | NEW BENZIMIDAZOLONE DERIVATIVES DISPLAYING AFFINITY AT THE SEROTONIN AND DOPAMINE RECEPTORS | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2003-07-02 | — | — | EP | disclosed |
| US-6586435-B2 | Useful in treatment of anxiety disorders, affective disorders such as depression, psychosis and schizophrenia, Parkinson's disease | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-07-01 | — | — | US | disclosed |
| US-20020103208-A1 | Benzimidazolone derivatives displaying affinity at the serotonin and dopamine receptors | BAUSCH HEALTH POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA (F/K/A VALEANT PHARMA POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA) (PL) | 2002-08-01 | — | — | US | disclosed |
| WO-2002024662-A1 | NEW BENZIMIDAZOLONE DERIVATIVES DISPLAYING AFFINITY AT THE SEROTONIN AND DOPAMINE RECEPTORS | BOEHRINGER INGELHEIM PHARMA GMBH & KO. KG (DE) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103208-A1 | Benzimidazolone derivatives displaying affinity at the serotonin and dopamine receptors | OPRM1, HTR2C, HTR1D | MEN1 3095/4885CYP1A2 517/4885KMT2A 3473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.