Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6840123 | 0.90 | ALDH1A1 (0.55) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5819182 | 0.87 | TGFBR1 (0.57) | ALDH1A1MAPTMAPK1KDM4ENPSR1 | |
| SCHEMBL5818242 | 0.87 | MAPK14 (0.47) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5812178 | 0.86 | TGFBR1 (0.61) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5819641 | 0.86 | TGFBR1 (0.45) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5815379 | 0.85 | MYC (0.47) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5817815 | 0.83 | MAPK14 (0.44) | MAPK1KDM4ENPSR1L3MBTL1MAPK13 | |
| SCHEMBL5815955 | 0.83 | TGFBR1 (0.56) | MAPK1KDM4ENPSR1L3MBTL1MAPK13 | |
| SCHEMBL1641146 | 0.81 | MYC (0.52) | ALDH1A1MAPTMAPK1KDM4ENPSR1 | |
| SCHEMBL24760755 | 0.80 | ALDH1A1 (0.59) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105517-B2 | Thiazolyl substituted aminopyrimidines as plant protection agents | SYNGENTA CROP PROTECTION, INC. (US) | 2006-09-12 | — | — | US | disclosed |
| EP-1434776-B1 | THIAZOLYL SUBSTITUTED AMINOPYRIMIDINES AS PLANT PROTECTION AGENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2006-06-28 | — | — | EP | disclosed |
| US-20050038059-A1 | Thiazolyl substituted aminopyrimidines as plant protection agents | SYNGENTA CROP PROTECTION, INC. | 2005-02-17 | — | — | US | disclosed |
| EP-1434776-A1 | THIAZOLYL SUBSTITUTED AMINOPYRIMIDINES AS PLANT PROTECTION AGENTS | Syngenta Participations AG (CH) | 2004-07-07 | — | — | EP | disclosed |
| WO-2003029249-A1 | THIAZOLYL SUBSTITUTED AMINOPYRIMIDINES AS PLANT PROTECTION AGENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038059-A1 | Thiazolyl substituted aminopyrimidines as plant protection agents | RARS2, CYP4X1, QDPR | ALDH1A1 243/4885MAPT 1623/4885CYP1A2 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.