Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5779062 | 0.99 | KDM4E (0.43) | KDM4EHTR7ALDH1A1SMN1; SMN2HRH1 | |
| SCHEMBL5781445 | 0.95 | HTR7 (0.48) | KDM4EHTR7ALDH1A1SMN1; SMN2MAOB | |
| Hydrochloric Acid SCHEMBL5785010 | 0.94 | HTR7 (0.47) | KDM4EHTR7ALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL10636445 | 0.84 | SHMT2 (0.43) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6766532 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1SMN1; SMN2HRH1 | |
| SCHEMBL5781776 | 0.81 | HTR7 (0.38) | KDM4EHTR7ALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL6763534 | 0.81 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2HRH1 | |
| Hydrochloric Acid SCHEMBL6773276 | 0.81 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2HRH1 | |
| Hydrochloric Acid SCHEMBL5780676 | 0.81 | HTR7 (0.37) | KDM4EHTR7ALDH1A1SMN1; SMN2HRH1 | |
| SCHEMBL5781166 | 0.81 | HTR7 (0.46) | KDM4EHTR7ALDH1A1SMN1; SMN2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153922-B1 | HETERODIAZINONE DERIVATIVES | EISAI CO LTD (JP) | 2006-04-26 | — | — | EP | claimed |
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | claimed |
| EP-1153922-B1 | HETERODIAZINONE DERIVATIVES | EISAI CO LTD (JP) | 2006-04-26 | — | — | EP | disclosed |
| US-6825192-B1 | NON-N-METHYL-D-ASPARTATE (NON- NMDA) EXCITATORY AMINO ACID RECEPTOR ANTAGONISTIC ACTION, FOR EXAMPLE 2-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) RECEPTOR ANTAGONISTIC ACTION | EISAI CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | disclosed |