Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | DRD5 | P21918 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6763508 | 0.99 | KDM4E (0.52) | KDM4ESMN1; SMN2CYP2D6ALDH1A1HTT | |
| SCHEMBL6766532 | 0.94 | KDM4E (0.53) | KDM4ESMN1; SMN2CYP2D6ALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL6773276 | 0.93 | KDM4E (0.52) | KDM4ESMN1; SMN2CYP2D6ALDH1A1HTT | |
| SCHEMBL5779094 | 0.92 | KDM4E (0.54) | KDM4ESMN1; SMN2ALDH1A1L3MBTL1POLB | |
| Hydrochloric Acid SCHEMBL6768032 | 0.91 | KDM4E (0.53) | KDM4EALDH1A1HTTL3MBTL1LMNA | |
| SCHEMBL6768461 | 0.87 | TDP1 (0.41) | KDM4ESMN1; SMN2CYP2D6KMT2AMEN1 | |
| SCHEMBL6763407 | 0.86 | TSHR (0.42) | KDM4ESMN1; SMN2CYP2D6KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL6766915 | 0.86 | TDP1 (0.40) | KDM4ESMN1; SMN2CYP2D6KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL6766958 | 0.85 | TSHR (0.41) | KDM4ESMN1; SMN2CYP2D6KMT2AMEN1 | |
| SCHEMBL5780359 | 0.85 | KDM4E (0.49) | KDM4EL3MBTL1POLBDRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | claimed |
| US-6825192-B1 | NON-N-METHYL-D-ASPARTATE (NON- NMDA) EXCITATORY AMINO ACID RECEPTOR ANTAGONISTIC ACTION, FOR EXAMPLE 2-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) RECEPTOR ANTAGONISTIC ACTION | EISAI CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | disclosed |