Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24164529 | 0.87 | LMNA (0.59) | LMNAPKMCCNT1CCNE1CDK2 | |
| SCHEMBL24164421 | 0.84 | LMNA (0.57) | LMNAPKMCCNT1CCNE1CDK2 | |
| SCHEMBL26210939 | 0.81 | SMN1; SMN2 (0.55) | LMNAPKMALDH1A1MAPK1MEN1 | |
| SCHEMBL26210846 | 0.81 | AOX1 (0.56) | LMNAPKMALDH1A1MAPK1MEN1 | |
| SCHEMBL11996634 | 0.81 | NPC1 (0.62) | LMNAPKMALDH1A1MAPK1MEN1 | |
| SCHEMBL2747362 | 0.79 | MAP4K4 (0.54) | LMNAPKMALDH1A1MAPK1MEN1 | |
| SCHEMBL30222110 | 0.79 | PKM (0.61) | LMNAPKMCCNT1CCNE1CDK2 | |
| SCHEMBL24333218 | 0.79 | ALDH1A1 (0.52) | LMNAPKMALDH1A1MAPK1MEN1 | |
| SCHEMBL4661410 | 0.79 | PKM (0.61) | LMNAPKMCCNT1CCNE1CDK2 | |
| SCHEMBL13950380 | 0.79 | TP53BP1 (0.60) | LMNAPKMALDH1A1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682531-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005042518-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2005-05-12 | — | — | WO | disclosed |