Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | CCR4 | P51679 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL577982 | 0.86 | CCR4 (0.33) | TYK2CCR4PARP1 | |
| SCHEMBL577505 | 0.82 | ALDH1A1 (0.36) | TYK2CCR4 | |
| SCHEMBL577976 | 0.82 | TYK2 (0.39) | TYK2CCR4 | |
| SCHEMBL577639 | 0.78 | APLNR (0.33) | TYK2 | |
| SCHEMBL577981 | 0.77 | TYK2 (0.35) | TYK2CCR4 | |
| SCHEMBL577703 | 0.75 | APLNR (0.32) | — | |
| SCHEMBL577504 | 0.75 | TYK2 (0.34) | TYK2CCR4 | |
| SCHEMBL23367842 | 0.74 | TYK2 (0.56) | TYK2CCR4 | |
| SCHEMBL577608 | 0.74 | SLC10A2 (0.35) | — | |
| SCHEMBL577533 | 0.73 | APLNR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417134-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX Pharmaceuticals, Inc. (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010118078-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |