Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 3/20 | 0.88 |
| ▸ | PABPC1 | P11940 | 3/20 | 0.88 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.79 |
| ▸ | POLB | P06746 | 6/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | STAT6 | P42226 | 1/20 | 0.63 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.63 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.63 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | RAD52 | P43351 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mitonafide SCHEMBL62046 | 0.94 | FTO (1.00) | FTOPABPC1CYP2D6POLBMEN1 | |
| Mitonafide SCHEMBL29352711 | 0.94 | FTO (1.00) | FTOPABPC1CYP2D6POLBMEN1 | |
| Mitonafide SCHEMBL29499462 | 0.94 | FTO (1.00) | FTOPABPC1CYP2D6POLBMEN1 | |
| Mitonafide SCHEMBL5166813 | 0.92 | FTO (0.98) | FTOPABPC1CYP2D6POLBMEN1 | |
| SCHEMBL9017071 | 0.91 | FTO (0.71) | FTOPABPC1CYP2D6POLBMEN1 | |
| Amonafide SCHEMBL27226 | 0.89 | FTO (1.00) | FTOPABPC1CYP2D6POLBMEN1 | |
| Amonafide SCHEMBL29352008 | 0.89 | FTO (1.00) | FTOPABPC1CYP2D6POLBMEN1 | |
| Amonafide SCHEMBL6255345 | 0.89 | FTO (1.00) | FTOPABPC1CYP2D6POLBMEN1 | |
| Amonafide SCHEMBL1566668 | 0.88 | FTO (0.97) | FTOPABPC1CYP2D6POLBMEN1 | |
| Amonafide SCHEMBL1051955 | 0.88 | FTO (0.97) | FTOPABPC1CYP2D6POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539150-A4 | NAPHTHALIMIDE SYNTHESIS INCLUDING AMONAFIDE SYNTHESIS AND PHARMACEUTICAL PREPARATIONS THEREOF | CHEMGENEX PHARMACEUTICALS INC (US) | 2006-10-11 | — | — | EP | disclosed |
| EP-1539150-A1 | NAPHTHALIMIDE SYNTHESIS INCLUDING AMONAFIDE SYNTHESIS AND PHARMACEUTICAL PREPARATIONS THEREOF | Chemgenex Pharmaceuticals Limited (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004004716-A1 | NAPHTHALIMIDE SYNTHESIS INCLUDING AMONAFIDE SYNTHESIS AND PHARMACEUTICAL PREPARATIONS THEREOF | CHEMGENEX PHARMACEUTICALS LIMITED (US) | 2004-01-15 | — | — | WO | disclosed |