Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 6/20 | 0.66 |
| ▸ | PGR | P06401 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.57 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.56 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.56 |
| ▸ | TDP2 | O95551 | 1/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.50 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1903306 | 0.88 | KIF11 (0.80) | KIF11PGRCYP1A2CYP11B1CYP11B2 | |
| SCHEMBL3315694 | 0.87 | KIF11 (0.79) | KIF11PGRCYP1A2CYP11B1CYP11B2 | |
| SCHEMBL25094235 | 0.86 | PGR (0.63) | KIF11PGRCYP1A2CYP11B1CYP11B2 | |
| SCHEMBL31492431 | 0.83 | TDP2 (0.66) | KIF11PDE3BPDE3ATDP2GAA | |
| SCHEMBL578303 | 0.83 | TDP2 (0.66) | KIF11PDE3BPDE3ATDP2GAA | |
| SCHEMBL3132725 | 0.81 | PGR (0.73) | KIF11PGRCYP1A2CYP11B1CYP11B2 | |
| SCHEMBL1900363 | 0.81 | PGR (0.68) | KIF11PGRCYP1A2CYP11B1CYP11B2 | |
| SCHEMBL1902698 | 0.80 | KIF11 (0.59) | KIF11PGRCYP1A2CYP11B1CYP11B2 | |
| SCHEMBL16208518 | 0.80 | KIF11 (1.00) | KIF11GAA | |
| SCHEMBL3313408 | 0.79 | KIF11 (0.62) | KIF11TDP2PARP10PARP11ASIC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011056985-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2011-05-12 | — | — | WO | disclosed |
| US-4670566-A | ANTIIFLAMMATORY AGENTS, ANTICOAGULANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-06-02 | — | — | US | disclosed |
| US-4440785-A | Methods of using 2-aminobiphenylacetic acids, esters, and metal salts thereof to treat inflammation | A. H. ROBINS COMPANY, INC. (US) | 1984-04-03 | — | — | US | disclosed |