Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 1/20 | 0.59 |
| ▸ | DNPH1 | O43598 | 10/20 | 0.57 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.57 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.57 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.57 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.57 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.57 |
| ▸ | LDHA | P00338 | 1/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.57 |
| ▸ | FBP1 | P09467 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.57 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.57 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.57 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine Phosphate SCHEMBL18730264 | 0.93 | EZH2 (0.70) | EZH2DNPH1TAS1R3TAS1R1P2RY1 | |
| Adenosine Phosphate SCHEMBL15670455 | 0.93 | EZH2 (0.70) | EZH2DNPH1TAS1R3TAS1R1P2RY1 | |
| Inosine SCHEMBL27610579 | 0.89 | NNMT (0.59) | EZH2NNMT | |
| Inosine SCHEMBL6764071 | 0.89 | NNMT (0.59) | EZH2NNMT | |
| SCHEMBL6764072 | 0.88 | MARS1 (0.59) | EZH2ADORA1NNMT | |
| SCHEMBL6764075 | 0.88 | MARS1 (0.59) | EZH2ADORA1NNMT | |
| Adenosine Phosphate SCHEMBL15670688 | 0.87 | EZH2 (0.61) | EZH2DNPH1TAS1R3TAS1R1P2RY1 | |
| Glutamic Acid SCHEMBL30621216 | 0.86 | DNPH1 (0.65) | EZH2DNPH1TAS1R3TAS1R1P2RY1 | |
| E626 SCHEMBL15671046 | 0.84 | KRAS (0.62) | TAS1R3TAS1R1 | |
| SCHEMBL25168081 | 0.82 | DNPH1 (0.79) | DNPH1TAS1R3TAS1R1P2RY1PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821692-B1 | IMMUNOPOTENTIATING INOSINE MONOPHOSPHATE 5'-NUCLEOTIDASE RESISTANT DERIVATIVES AND USES THEREOF | UNIV SOUTH FLORIDA (US) | 2006-01-11 | — | — | EP | claimed |
| EP-1459760-A9 | Immunopotentiating inosine monophosphate 5'-nucleotidase resistant derivatives and uses thereof | UNIVERSITY OF SOUTH FLORIDA (US) | 2005-01-12 | — | — | EP | claimed |
| EP-1459760-A1 | Immunopotentiating inosine monophosphate 5'-nucleotidase resistant derivatives and uses thereof | UNIVERSITY OF SOUTH FLORIDA (US) | 2004-09-22 | — | — | EP | claimed |
| US-5614504-A | Method of making inosine monophosphate derivatives and immunopotentiating uses thereof | THE UNIVERSITY OF SOUTH FLORIDA (US) | 1997-03-25 | — | — | US | claimed |
| EP-0821692-B1 | IMMUNOPOTENTIATING INOSINE MONOPHOSPHATE 5'-NUCLEOTIDASE RESISTANT DERIVATIVES AND USES THEREOF | UNIV SOUTH FLORIDA (US) | 2006-01-11 | — | — | EP | disclosed |
| EP-1459760-A9 | Immunopotentiating inosine monophosphate 5'-nucleotidase resistant derivatives and uses thereof | UNIVERSITY OF SOUTH FLORIDA (US) | 2005-01-12 | — | — | EP | disclosed |
| EP-1459760-A1 | Immunopotentiating inosine monophosphate 5'-nucleotidase resistant derivatives and uses thereof | UNIVERSITY OF SOUTH FLORIDA (US) | 2004-09-22 | — | — | EP | disclosed |
| EP-0821692-A1 | IMMUNOPOTENTIATING INOSINE MONOPHOSPHATE 5'-NUCLEOTIDASE RESISTANT DERIVATIVES AND USES THEREOF | UNIVERSITY OF SOUTH FLORIDA (US) | 1998-02-04 | — | — | EP | disclosed |
| US-5614504-A | Method of making inosine monophosphate derivatives and immunopotentiating uses thereof | THE UNIVERSITY OF SOUTH FLORIDA (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1996033203-A1 | IMMUNOPOTENTIATING INOSINE MONOPHOSPHATE 5'-NUCLEOTIDASE RESISTANT DERIVATIVES AND USES THEREOF | UNIVERSITY OF SOUTH FLORIDA (US) | 1996-10-24 | — | — | WO | disclosed |