Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5784325 | 0.84 | RAB9A (0.41) | ALDH1A1MAPTGFERKDM4EHPGD | |
| SCHEMBL4930122 | 0.77 | YTHDC1 (0.43) | ALDH1A1MAPTGFERKDM4EHPGD | |
| SCHEMBL5364636 | 0.73 | YTHDC1 (0.43) | ALDH1A1MAPTGFERKDM4EHPGD | |
| SCHEMBL20389460 | 0.73 | MAPK1 (0.42) | ALDH1A1MAPTGFERKDM4EHPGD | |
| SCHEMBL5786736 | 0.70 | ALDH1A1 (0.46) | ALDH1A1MAPTGFERKDM4EHPGD | |
| SCHEMBL15017190 | 0.70 | ADORA3 (0.43) | ALDH1A1MAPTGFERKDM4EHPGD | |
| SCHEMBL12692147 | 0.69 | GRM5 (0.55) | GRM5MEN1KMT2AADORA1 | |
| SCHEMBL18040266 | 0.69 | DPP4 (0.49) | ALDH1A1MAPTGFERKDM4EHPGD | |
| SCHEMBL15698438 | 0.69 | ALDH1A1 (0.40) | ALDH1A1MAPTGFERKDM4EHPGD | |
| SCHEMBL5787312 | 0.69 | HPGD (0.41) | ALDH1A1MAPTGFERKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507780-A4 | PYRAZOLO-PYRIMIDINE ANILINE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2006-08-02 | — | — | EP | disclosed |
| EP-1507780-A1 | PYRAZOLO-PYRIMIDINE ANILINE COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003099820-A1 | PYRAZOLO-PYRIMIDINE ANILINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-12-04 | — | — | WO | disclosed |