Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.71 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.71 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4820552 | 0.92 | SIRT6 (0.64) | SIRT6ADRB1KCNJ1KCNH2POLB | |
| SCHEMBL4817023 | 0.87 | SIRT6 (0.71) | SIRT6ADRB1KCNJ1KCNH2POLB | |
| SCHEMBL6151805 | 0.86 | SIRT6 (0.96) | SIRT6ADRB1KCNJ1KCNH2POLB | |
| SCHEMBL5780433 | 0.85 | KMT2A (0.58) | SIRT6POLBKMT2AHTR1AMAPT | |
| SCHEMBL7526992 | 0.84 | SIRT6 (1.00) | SIRT6ADRB1KCNJ1KCNH2POLB | |
| SCHEMBL336262 | 0.84 | SIRT6 (1.00) | SIRT6ADRB1KCNJ1KCNH2POLB | |
| Hydrochloric Acid SCHEMBL1814630 | 0.83 | SIRT6 (0.96) | SIRT6ADRB1KCNJ1KCNH2POLB | |
| SCHEMBL1496058 | 0.83 | SIRT6 (0.96) | SIRT6ADRB1KCNJ1KCNH2POLB | |
| SCHEMBL6152151 | 0.83 | SIRT6 (0.96) | SIRT6ADRB1KCNJ1KCNH2POLB | |
| Hydrogen Sulfide SCHEMBL28002215 | 0.83 | SIRT6 (0.96) | SIRT6ADRB1KCNJ1KCNH2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654238-A1 | 2-AMINOPYRIMIDINE AND 2-AMINOPYRIDINE-4-CARBAMATES FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AMGEN INC. (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005009978-A1 | 2-AMINOPYRIMIDINE AND 2-AMINOPYRIDINE-4-CARBAMATES FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |