Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.71 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.71 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ESRRG | P62508 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717022 | 0.92 | SIRT6 (0.64) | SIRT6HTR1AKMT2APOLBMAPT | |
| SCHEMBL6151796 | 0.92 | SIRT6 (0.64) | SIRT6HTR1AKMT2APOLBMAPT | |
| SCHEMBL5784690 | 0.87 | SIRT6 (0.71) | SIRT6ADRB1HTR1AKCNJ1KCNH2 | |
| SCHEMBL5206660 | 0.86 | LMNA (0.63) | SIRT6HTR1AKMT2APOLBMAPT | |
| SCHEMBL6151805 | 0.86 | SIRT6 (0.96) | SIRT6ADRB1HTR1AKCNJ1KCNH2 | |
| SCHEMBL5780433 | 0.85 | KMT2A (0.58) | SIRT6HTR1AKMT2APOLBMAPT | |
| SCHEMBL336262 | 0.84 | SIRT6 (1.00) | SIRT6ADRB1HTR1AKCNJ1KCNH2 | |
| SCHEMBL7526992 | 0.84 | SIRT6 (1.00) | SIRT6ADRB1HTR1AKCNJ1KCNH2 | |
| SCHEMBL5743368 | 0.83 | HTR1A (0.61) | SIRT6HTR1AKCNJ1KMT2APOLB | |
| SCHEMBL1496058 | 0.83 | SIRT6 (0.96) | SIRT6ADRB1HTR1AKCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442698-B2 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2008-10-28 | — | — | US | disclosed |