Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4820552 | 0.93 | SIRT6 (0.64) | KMT2AHTR1ASIRT6POLBMAPT | |
| SCHEMBL2717022 | 0.93 | SIRT6 (0.64) | KMT2AHTR1ASIRT6POLBMAPT | |
| SCHEMBL6151796 | 0.93 | SIRT6 (0.64) | KMT2AHTR1ASIRT6POLBMAPT | |
| SCHEMBL5206660 | 0.88 | LMNA (0.63) | KMT2AHTR1ASIRT6POLBMAPT | |
| SCHEMBL4817023 | 0.85 | SIRT6 (0.71) | KMT2AHTR1ASIRT6POLBMAPT | |
| SCHEMBL5784690 | 0.85 | SIRT6 (0.71) | KMT2AHTR1ASIRT6POLBMAPT | |
| SCHEMBL5743368 | 0.85 | HTR1A (0.61) | KMT2AHTR1ASIRT6POLBMAPT | |
| SCHEMBL9436570 | 0.82 | HTR1A (0.58) | KMT2AHTR1ASIRT6POLBMAPT | |
| SCHEMBL27178667 | 0.81 | KMT2A (0.60) | KMT2AHTR1ASIRT6POLBMAPT | |
| SCHEMBL9383629 | 0.80 | HTR1A (0.56) | KMT2AHTR1ASIRT6POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682531-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005042518-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2005-05-12 | — | — | WO | disclosed |