Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GNRHR | P30968 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599184 | 1.00 | POLB (0.32) | POLBHPGDGNRHRDPP4ALDH1A1 | |
| SCHEMBL5599338 | 0.89 | F10 (0.35) | POLBHPGDGNRHRDPP4ALDH1A1 | |
| SCHEMBL5786885 | 0.82 | GNRHR (0.33) | GNRHRDPP4KCNH2 | |
| SCHEMBL5784847 | 0.81 | GNRHR (0.34) | GNRHRDPP4KCNH2 | |
| SCHEMBL5780824 | 0.81 | GNRHR (0.37) | GNRHRDPP4KCNH2 | |
| SCHEMBL5784997 | 0.81 | GNRHR (0.32) | HPGDGNRHRDPP4ALDH1A1KCNH2 | |
| SCHEMBL5786887 | 0.79 | GNRHR (0.41) | GNRHRKCNH2 | |
| SCHEMBL5599105 | 0.79 | CHRNB2 (0.34) | GNRHRDPP4KCNH2 | |
| SCHEMBL5599768 | 0.79 | GNRHR (0.36) | GNRHRDPP4KCNH2 | |
| SCHEMBL5780422 | 0.79 | P2RX7 (0.36) | HPGDGNRHRDPP4ALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |