Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | BLVRB | P30043 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5787184 | 0.83 | KEAP1 (0.50) | KEAP1POLBKDM4EALDH1A1TDP1 | |
| SCHEMBL4601674 | 0.81 | MAOB (0.58) | KEAP1POLBKDM4EALDH1A1TDP1 | |
| SCHEMBL5786569 | 0.79 | RXRA (0.51) | KEAP1POLBKDM4EALDH1A1TDP1 | |
| SCHEMBL31346192 | 0.76 | MAOB (0.64) | MAOAMAOB | |
| SCHEMBL4602054 | 0.76 | MAPT (0.56) | KDM4EALDH1A1HDAC6MAOAFFAR1 | |
| SCHEMBL977340 | 0.74 | FFAR1 (0.58) | HDAC6FFAR1MAOB | |
| SCHEMBL977056 | 0.74 | HDAC6 (0.73) | KDM4EALDH1A1KMOHDAC6PTGS2 | |
| SCHEMBL13137668 | 0.72 | KMO (0.63) | KEAP1KDM4EALDH1A1KMOHDAC6 | |
| SCHEMBL28381454 | 0.71 | MAPT (0.51) | KDM4EALDH1A1L3MBTL1HDAC6MAOA | |
| SCHEMBL977613 | 0.70 | HDAC3 (0.62) | KDM4EALDH1A1HDAC6MAOAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060205751-A1 | Novel compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-09-14 | — | — | US | claimed |
| EP-1648885-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-26 | — | — | EP | claimed |
| WO-2005009993-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-03 | — | — | WO | claimed |
| US-20060205751-A1 | Novel compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-09-14 | — | — | US | disclosed |
| EP-1648885-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009993-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205751-A1 | Novel compounds | KCNN2, KCNN3, KCNN1 | KEAP1 1377/4885POLB 4222/4885KDM4E 1841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.