Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | AGER | Q15109 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9737760 | 0.81 | LMNA (0.56) | RIPK1SMN1; SMN2LMNAALDH1A1L3MBTL1 | |
| SCHEMBL4406065 | 0.79 | NAPRT (0.58) | RIPK1TSHRP2RX4NAPRTSMN1; SMN2 | |
| SCHEMBL14626001 | 0.79 | RIPK1 (0.43) | RIPK1TSHRP2RX4NAPRTSMN1; SMN2 | |
| SCHEMBL13714099 | 0.76 | LMNA (0.44) | TSHRNAPRTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL9735902 | 0.75 | MAPT (0.44) | RIPK1TSHRP2RX4SMN1; SMN2LMNA | |
| SCHEMBL30023037 | 0.74 | SMN1; SMN2 (0.60) | TSHRNAPRTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL1310961 | 0.74 | SMN1; SMN2 (0.60) | TSHRNAPRTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL24631848 | 0.74 | SMN1; SMN2 (0.36) | TSHRNAPRTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL4556787 | 0.73 | TDP1 (0.54) | TSHRLMNAKDM4ETDP1ALDH1A1 | |
| SCHEMBL5929445 | 0.73 | KDM4E (0.43) | RIPK1TSHRP2RX4NAPRTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664027-A1 | SUBSTITUTED 2,3-DIHYDRO-1H-ISOINDOL-1-ONE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005021532-A1 | SUBSTITUTED 2,3-DIHYDRO-1H-ISOINDOL-1-ONE DERIVATIVES AND METHODS OF USE | AMGEN INC (US) | 2005-03-10 | — | — | WO | disclosed |