Sugi Predict

Sugi Predict / Compounds / SCHEMBL578797

SCHEMBL578797

SCHEMBL578797

N#Cc1c[nH]c2cc(Br)ccc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IMPDH2 P12268 4/20 0.56
▸ IMPDH1 P20839 1/20 0.56
▸ CYP2A6 P11509 1/20 0.50
▸ CHEK1 O14757 1/20 0.47
▸ CCNT1 O60563 1/20 0.46
▸ CDK9 P50750 1/20 0.46
▸ HASPIN Q8TF76 1/20 0.46
▸ CSNK2A1 P68400 1/20 0.46
▸ DYRK1A Q13627 2/20 0.46
▸ CHRNB2 P17787 1/20 0.44
▸ CHRNA7 P36544 1/20 0.44
▸ CHRNA4 P43681 1/20 0.44
▸ ADRA1A P35348 1/20 0.42
▸ ADRA1B P35368 1/20 0.42
▸ GPR84 Q9NQS5 1/20 0.41
▸ CLK1 P49759 2/20 0.40
▸ CDK5 Q00535 2/20 0.40
▸ CDK5R1 Q15078 2/20 0.40
▸ CCNB2 O95067 1/20 0.40
▸ CDK1 P06493 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30665808 1.00 IMPDH2 (0.56) IMPDH2IMPDH1CYP2A6CHEK1CCNT1
SCHEMBL5253807 0.86 CHEK1 (0.49) IMPDH2IMPDH1CYP2A6CHEK1CCNT1
SCHEMBL186728 0.85 CSNK2A1 (0.58) IMPDH2IMPDH1CHEK1CCNT1CDK9
Indoline SCHEMBL13387076 0.80 IMPDH2 (0.46) IMPDH2IMPDH1CYP2A6CHEK1CCNT1
SCHEMBL28485389 0.79 PTGES (0.51) IMPDH2IMPDH1CYP2A6CSNK2A1CHRNB2
SCHEMBL10095346 0.78 IMPDH2 (0.56) IMPDH2IMPDH1CYP2A6CHEK1CCNT1
SCHEMBL187169 0.78 IMPDH2 (0.56) IMPDH2IMPDH1CCNT1CDK9HASPIN
SCHEMBL6600237 0.78 IMPDH2 (0.56) IMPDH2IMPDH1CCNT1CDK9HASPIN
SCHEMBL394651 0.78 IMPDH2 (0.56) IMPDH2IMPDH1CCNT1CDK9HASPIN
SCHEMBL13181942 0.78 IMPDH2 (0.56) IMPDH2IMPDH1CCNT1CDK9HASPIN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114805664-B Bionic modified marine antifouling resin material, and preparation method and application thereof 江苏苏博特新材料股份有限公司 2023-04-14 — — CN claimed
CN-114805664-A Bionic modified marine antifouling resin material, and preparation method and application thereof 江苏苏博特新材料股份有限公司 2022-07-29 — — CN claimed
CN-114292582-B Hyperbranched coating suitable for marine concrete, and preparation method and application thereof 江苏苏博特新材料股份有限公司 2022-07-12 — — CN claimed
CN-114292582-A Hyperbranched coating suitable for marine concrete, and preparation method and application thereof 江苏苏博特新材料股份有限公司 2022-04-08 — — CN claimed
US-20250353830-A1 NOVEL COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 2025-11-20 — — US disclosed
US-20250114345-A1 COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF ONCOPIA THERAPEUTICS, INC. D/B/A/ SK LIFE SCIENCE LABS 2025-04-10 — — US disclosed
WO-2025049994-A1 COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF ONCOPIA THERAPEUTICS, INC. D/B/A SK LIFE SCIENCE LABS (US) 2025-03-06 — — WO disclosed
CN-119300833-A Novel compounds 豪夫迈·罗氏有限公司 2025-01-10 — — CN disclosed
US-20250002471-A1 6-SUBSTITUTED INDOLE COMPOUNDS GILEAD SCIENCES, INC. 2025-01-02 — — US disclosed
EP-4387965-A2 ARYL SULFONYL COMPOUNDS AS CCR6 INHIBITORS ChemoCentryx, Inc. (US) 2024-06-26 — — EP disclosed
US-12012403-B2 Aryl sulfonyl compounds as CCR6 inhibitors CHEMOCENTRYX, INC. (US) 2024-06-18 — — US disclosed
CN-118019735-A Arylsulfonyl compounds as CCR6 inhibitors 坎莫森特里克斯公司 2024-05-10 — — CN disclosed
US-7446118-B2 3-amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof ROCHE PALO ALTO LLC (US) 2008-11-04 — — US disclosed
US-7446118-B2 3-amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof ROCHE PALO ALTO LLC (US) 2008-11-04 — — US disclosed
EP-1960355-A1 3-AMINO-1-ARYLPROPYL INDOLES AND AZA-SUBSTITUTED INDOLES F.HOFFMANN-LA ROCHE AG (CH) 2008-08-27 — — EP disclosed
CN-101219986-A 3-cyanogen radical indole compounds and its synthetic method SHANGHAI CHEMPARTNER CO LTD (CN) 2008-07-16 — — CN disclosed
WO-2007062996-A1 3-AMINO-1-ARYLPROPYL INDOLES AND AZA-SUBSTITUTED INDOLES F. HOFFMANN-LA ROCHE AG (CH) 2007-06-07 — — WO disclosed
WO-2007062996-A1 3-AMINO-1-ARYLPROPYL INDOLES AND AZA-SUBSTITUTED INDOLES F. HOFFMANN-LA ROCHE AG (CH) 2007-06-07 — — WO disclosed
US-20070123527-A1 3-Amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof ROCHE PALO ALTO LLC 2007-05-31 — — US disclosed
US-20070123527-A1 3-Amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof ROCHE PALO ALTO LLC 2007-05-31 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070123527-A1 3-Amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof IDO1, RB1, AHR IMPDH2 720/4885IMPDH1 369/4885CYP2A6 74/4885
US-20250002471-A1 6-SUBSTITUTED INDOLE COMPOUNDS SSB, IDO1, IDO2 IMPDH2 1838/4885IMPDH1 2036/4885CYP2A6 592/4885
US-12012403-B2 Aryl sulfonyl compounds as CCR6 inhibitors CCR6, CCR1, CCR3 IMPDH2 4245/4885IMPDH1 4039/4885CYP2A6 32/4885
US-20250114345-A1 COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF EP300, CREBBP, HDAC1 IMPDH2 4550/4885IMPDH1 4340/4885CYP2A6 2204/4885
US-20250353830-A1 NOVEL COMPOUNDS UQCRB, CCNB3, C5 IMPDH2 2490/4885IMPDH1 2055/4885CYP2A6 682/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.