Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | FPR1 | P21462 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5759864 | 0.90 | FPR2 (0.50) | FPR2KDM4EMAPTFPR1MCHR1 | |
| SCHEMBL5760906 | 0.88 | KDM4E (0.52) | KDM4EMAPTGFERMEN1KMT2A | |
| SCHEMBL5762686 | 0.87 | FPR2 (0.48) | FPR2KDM4EMAPTROCK2MCHR1 | |
| SCHEMBL5759972 | 0.87 | KDM4E (0.55) | KDM4EMAPTROCK2MCHR1GFER | |
| SCHEMBL5762942 | 0.87 | ROCK2 (0.49) | KDM4EMAPTROCK2MCHR1 | |
| Hydrochloric Acid SCHEMBL5808241 | 0.86 | FPR2 (0.47) | FPR2KDM4EMAPTROCK2MCHR1 | |
| SCHEMBL5763072 | 0.84 | ROCK2 (0.55) | FPR2KDM4EMAPTFPR1ROCK2 | |
| SCHEMBL5761785 | 0.75 | GPR119 (0.48) | MAPTMCHR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5761228 | 0.75 | DRD2 (0.40) | KDM4EMAPTROCK2MCHR1 | |
| SCHEMBL5845894 | 0.73 | KDM4E (0.41) | FPR2KDM4EMAPTFPR1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638932-A1 | NOVEL PIPERAZINYL-ARYLOXY AND PIPERAZINYL-HETEROARYLOXY-N-ARYL LACTAMS | Pfizer Products Inc. (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004110994-A1 | NOVEL PIPERAZINYL-ARYLOXY AND PIPERAZINYL-HETEROARYLOXY-N-ARYL LACTAMS | PFIZER PRODUCTS INC. (US) | 2004-12-23 | — | — | WO | disclosed |