Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | USP7 | Q93009 | 5/20 | 0.44 |
| ▸ | NR1I3 | Q14994 | 7/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5790886 | 0.84 | USP7 (0.48) | USP7NR1I3TP53GAAMAPT | |
| SCHEMBL5790097 | 0.83 | CDK2 (0.43) | MAPK13MAPK12MAPK11MAPK14PIM1 | |
| SCHEMBL5788739 | 0.81 | IGF1R (0.51) | MAPK13MAPK12MAPK11MAPK14NR1I3 | |
| SCHEMBL5790032 | 0.81 | GAA (0.46) | MAPK13MAPK12MAPK11MAPK14NR1I3 | |
| SCHEMBL5792573 | 0.81 | TGFBR1 (0.45) | MAPK14PIM1USP7CDK2 | |
| SCHEMBL5789762 | 0.80 | PRKAB2 (0.48) | — | |
| SCHEMBL5792548 | 0.79 | TGFBR1 (0.52) | MAPK13MAPK12MAPK11MAPK14IGF1R | |
| SCHEMBL25790036 | 0.76 | NPC1 (0.56) | NR1I3NR1I2TP53GAAMAPT | |
| SCHEMBL5786829 | 0.75 | NR1I3 (0.41) | MAPK13MAPK12MAPK11MAPK14NR1I3 | |
| SCHEMBL5789074 | 0.73 | IGF1R (0.43) | MAPK13MAPK12MAPK11MAPK14NR1I3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543003-B1 | IMIDAZO¬1,2-A|PYRIDINES | SMITHKLINE BEECHAM CORP (US) | 2006-05-17 | — | — | EP | disclosed |
| US-20050234029-A1 | Compounds | DODIC NERINA | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234029-A1 | Compounds | SMAD3, SMAD2, ACVR1 | MAPK13 229/4885MAPK12 254/4885MAPK11 444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.