Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.37 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | AKT2 | P31751 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5786829 | 0.91 | NR1I3 (0.41) | IGF1RALDH1A1CSNK1DCSNK1EMAPK13 | |
| SCHEMBL5790871 | 0.85 | PTGS2 (0.44) | ALDH1A1CSNK1DCSNK1ENPC1RAB9A | |
| SCHEMBL5791351 | 0.81 | TGFBR1 (0.44) | ALDH1A1NPC1RAB9AMAPK14 | |
| SCHEMBL5789564 | 0.80 | IGF1R (0.48) | IGF1RALDH1A1NR1I3KDM4EINSR | |
| SCHEMBL5788405 | 0.80 | KLK7 (0.44) | IGF1RALDH1A1KLK7CSNK1DCSNK1E | |
| SCHEMBL1428788 | 0.76 | AKT1 (0.50) | ALDH1A1CSNK1DCSNK1ENPC1RAB9A | |
| SCHEMBL1429286 | 0.76 | ALDH1A1 (0.67) | ALDH1A1CSNK1DCSNK1ENPC1RAB9A | |
| SCHEMBL1428784 | 0.74 | AKT1 (0.60) | ALDH1A1NPC1RAB9AAKT1AKT2 | |
| SCHEMBL5789751 | 0.73 | MAPK13 (0.46) | IGF1RNPC1RAB9AMAPK13MAPK12 | |
| SCHEMBL5788291 | 0.73 | MAPT (0.48) | ALDH1A1CSNK1DCSNK1ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543003-B1 | IMIDAZO¬1,2-A|PYRIDINES | SMITHKLINE BEECHAM CORP (US) | 2006-05-17 | — | — | EP | disclosed |
| US-20050234029-A1 | Compounds | DODIC NERINA | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234029-A1 | Compounds | SMAD3, SMAD2, ACVR1 | IGF1R 34/4885ALDH1A1 2965/4885KLK7 4130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.