Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4833190 | 0.78 | MEN1 (0.41) | KMT2AMEN1POLBMAPTL3MBTL1 | |
| SCHEMBL4838017 | 0.78 | MEN1 (0.41) | KMT2AMEN1POLBMAPTL3MBTL1 | |
| SCHEMBL4841426 | 0.72 | ALDH1A1 (0.40) | KMT2AMEN1POLBMAPT | |
| SCHEMBL8319687 | 0.72 | ALDH1A1 (0.40) | KMT2AMEN1POLBMAPT | |
| SCHEMBL19985879 | 0.62 | FPR1 (0.56) | KMT2AMEN1POLBL3MBTL1TDP1 | |
| Hydrochloric Acid SCHEMBL19972298 | 0.62 | FPR1 (0.55) | POLBL3MBTL1TDP1PTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL19972295 | 0.62 | FPR1 (0.55) | POLBL3MBTL1TDP1PTGS1PTGS2 | |
| SCHEMBL28075046 | 0.61 | MAOA (0.47) | MAPTL3MBTL1KDM4ETDP1PTGS2 | |
| SCHEMBL5436952 | 0.60 | PDE10A (0.48) | L3MBTL1 | |
| SCHEMBL12227846 | 0.59 | DRD2 (0.54) | KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |