Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5791157 | 0.86 | HIF1A (0.42) | MAOBCHRM2HDAC1HDAC8HDAC6 | |
| SCHEMBL5791541 | 0.84 | PKM (0.45) | CHRM2KDM4EGAAHPGDTSHR | |
| SCHEMBL5789493 | 0.83 | PKM (0.49) | CHRM2KDM4EGAAHPGDTSHR | |
| SCHEMBL5792428 | 0.82 | PRKAA2 (0.45) | KDM4ETSHRSMN1; SMN2LDHALDHB | |
| SCHEMBL8277406 | 0.81 | PKM (0.47) | KDM4EGAAHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL8275457 | 0.81 | PKM (0.47) | KDM4EGAAHPGDTSHRNPC1 | |
| SCHEMBL8425448 | 0.81 | HPGD (0.56) | KDM4EGAAHPGDTSHRNPC1 | |
| SCHEMBL5790537 | 0.79 | CHRM2 (0.42) | MAOBCHRM2TSHRHTTNPSR1 | |
| SCHEMBL5791743 | 0.79 | PKM (0.43) | MAOBKDM4EGAATSHRNPC1 | |
| SCHEMBL5789524 | 0.78 | P2RX3 (0.40) | MAOBKDM4EGAATSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006002956-A1 | PIPERIDINE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORTER INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-01-12 | — | — | WO | claimed |
| WO-2006002956-A1 | PIPERIDINE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORTER INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-01-12 | — | — | WO | disclosed |
| WO-2006002956-A1 | PIPERIDINE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORTER INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-01-12 | — | — | WO | disclosed |