Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | CASR | P41180 | 5/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5792113 | 0.82 | GHSR (0.59) | GHSRCYP2D6CASRKCNH2BRD4 | |
| SCHEMBL5819936 | 0.75 | GHSR (0.58) | GHSRCYP2D6CASRKCNH2TDO2 | |
| SCHEMBL5792841 | 0.74 | GHSR (0.65) | GHSRCYP2D6CASRKCNH2 | |
| SCHEMBL5791517 | 0.71 | GHSR (0.75) | GHSRCYP2D6CASRKCNH2TDO2 | |
| SCHEMBL12788321 | 0.70 | POLB (0.59) | GHSRCYP2D6KCNH2POLBSMN1; SMN2 | |
| SCHEMBL6308155 | 0.70 | BRD4 (0.47) | GHSRCYP2D6BRD4F11SMN1; SMN2 | |
| SCHEMBL5823984 | 0.69 | CYP2D6 (0.76) | GHSRCYP2D6KCNH2 | |
| SCHEMBL6309011 | 0.65 | CASR (0.51) | CASRSMN1; SMN2 | |
| SCHEMBL12789762 | 0.65 | CYP2D6 (0.47) | GHSRCYP2D6CASRKCNH2POLB | |
| SCHEMBL12789754 | 0.65 | CYP2D6 (0.47) | GHSRCYP2D6CASRKCNH2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006012577-A2 | QUINAZOLINONE DERIVATIVES USEFUL FOR THE REGULATION OF GLUCOSE HOMEOSTASIS AND FOOD INTAKE | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |