Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 17/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.72 |
| ▸ | SPR | P35270 | 1/20 | 0.62 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.62 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL351449 | 0.92 | MPO (0.69) | MPOSLC6A4SPRNOTUMMTNR1A | |
| SCHEMBL16433186 | 0.88 | CYP1A2 (0.70) | MPOSLC6A4SPRNOTUMMTNR1A | |
| SCHEMBL20441315 | 0.86 | MPO (0.67) | MPOSLC6A4SPRNOTUMMTNR1A | |
| SCHEMBL5792523 | 0.85 | MPO (0.78) | MPOSLC6A4NOTUMMTNR1AMTNR1B | |
| SCHEMBL27602982 | 0.85 | SLC6A4 (0.59) | MPOSLC6A4NOTUMMTNR1AMTNR1B | |
| SCHEMBL7238856 | 0.85 | GFER (0.66) | MPOSLC6A4MTNR1AMTNR1B | |
| SCHEMBL5203631 | 0.84 | MPO (0.80) | MPOSLC6A4NOTUMMTNR1AMTNR1B | |
| SCHEMBL3695233 | 0.84 | MPO (1.00) | MPOSLC6A4NOTUMMTNR1AMTNR1B | |
| SCHEMBL3229556 | 0.84 | TSHR (0.69) | MPOSLC6A4SPRNOTUMMTNR1A | |
| SCHEMBL2405088 | 0.82 | MPO (0.67) | MPOSLC6A4SPRNOTUMMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651637-A1 | 3-AMINO CHROMAN AND 2-AMINO TETRALIN DERIVATIVES | Wyeth (US) | 2006-05-03 | — | — | EP | disclosed |
| US-20050032873-A1 | 3-Amino chroman and 2-amino tetralin derivatives | WYETH (US) | 2005-02-10 | — | — | US | disclosed |
| WO-2005012291-A1 | 3-AMINO CHOMAN AND 2-AMINO TETRALIN DERIVATIVES | WYETH (US) | 2005-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032873-A1 | 3-Amino chroman and 2-amino tetralin derivatives | TPH2, HTR2C, HTR7 | MPO 4464/4885SLC6A4 32/4885SPR 3753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.