Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10037412 | 0.86 | HIF1A (0.38) | CYP2C19 | |
| SCHEMBL338642 | 0.85 | HIF1A (0.36) | CYP2C19 | |
| SCHEMBL10037417 | 0.83 | TSHR (0.37) | CYP2C19 | |
| SCHEMBL595778 | 0.76 | CYP2C19 (0.37) | CYP2C19 | |
| SCHEMBL12208409 | 0.75 | CYP2C19 (0.35) | CYP2C19 | |
| SCHEMBL22492710 | 0.73 | — | — | |
| SCHEMBL8265849 | 0.72 | — | — | |
| SCHEMBL4774527 | 0.72 | CYP2C19 (0.36) | CYP2C19 | |
| SCHEMBL18435824 | 0.71 | ALDH1A1 (0.32) | — | |
| SCHEMBL11793751 | 0.71 | FFAR1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615643-A1 | 4-PHENYL-PIPERIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF OPIOID RECEPTORS | Pfizer Products Inc. (US) | 2006-01-18 | — | — | EP | disclosed |
| US-20050032837-A1 | 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors | PFIZER, INC. (US) | 2005-02-10 | — | — | US | disclosed |
| WO-2004089370-A1 | 4-PHENYL-PIPERIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF OPIOID RECEPTORS | PFIZER PRODUCTS INC. (US) | 2004-10-21 | — | — | WO | disclosed |
| US-20040204453-A1 | 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors | PFIZER INC | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032837-A1 | 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors | OPRD1, OPRK1, OPRM1 | CYP2C19 473/4885 |
| US-20040204453-A1 | 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors | OPRD1, OPRK1, OPRM1 | CYP2C19 473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.