Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CFB | P00751 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5796637 | 0.83 | LMNA (0.59) | SMN1; SMN2HCRTR1ALDH1A1LMNAMAPK1 | |
| SCHEMBL5820332 | 0.79 | LMNA (0.54) | SMN1; SMN2HCRTR1ALDH1A1LMNAMAPK1 | |
| SCHEMBL5794585 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2HCRTR1ALDH1A1LMNAMAPK1 | |
| SCHEMBL5806244 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2HCRTR1ALDH1A1LMNAMAPK1 | |
| SCHEMBL5795178 | 0.73 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1LMNAHTTNPSR1 | |
| SCHEMBL5793624 | 0.70 | HCRTR1 (0.40) | HCRTR1KDM4EATM | |
| SCHEMBL5794482 | 0.70 | MAPT (0.56) | SMN1; SMN2HCRTR1ALDH1A1LMNAMAPK1 | |
| SCHEMBL12125064 | 0.70 | MAPK1 (0.53) | SMN1; SMN2ALDH1A1MAPK1MAPTCFB | |
| SCHEMBL5796898 | 0.69 | UTS2R (0.42) | SMN1; SMN2ALDH1A1MAPK1HTTMAPT | |
| SCHEMBL5793715 | 0.69 | MAPT (0.47) | SMN1; SMN2LMNACYP2D6CYP2C9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006015279-A1 | HETEROCYCLIC DIAMINE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR USEFUL FOR THE TREATMENT OF OBESITY, DIABETES, EATING AND SEXUAL DISORDERS | NEUROGEN CORPORATION (US) | 2006-02-09 | — | — | WO | claimed |