Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 9/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5796637 | 0.92 | LMNA (0.59) | LMNAALDH1A1HTTSMN1; SMN2MAPK1 | |
| SCHEMBL5794585 | 0.86 | SMN1; SMN2 (0.44) | LMNAALDH1A1HTTSMN1; SMN2MAPK1 | |
| SCHEMBL5806244 | 0.84 | SMN1; SMN2 (0.43) | LMNAALDH1A1HTTSMN1; SMN2MAPK1 | |
| SCHEMBL5795178 | 0.81 | SMN1; SMN2 (0.54) | LMNAALDH1A1HTTSMN1; SMN2NPSR1 | |
| SCHEMBL5794482 | 0.80 | MAPT (0.56) | LMNAALDH1A1HTTSMN1; SMN2MAPK1 | |
| SCHEMBL5794095 | 0.79 | SMN1; SMN2 (0.42) | LMNAALDH1A1HTTSMN1; SMN2MAPK1 | |
| SCHEMBL5796898 | 0.78 | UTS2R (0.42) | ALDH1A1HTTSMN1; SMN2MAPK1MAPT | |
| SCHEMBL5793771 | 0.76 | SMN1; SMN2 (0.41) | ALDH1A1HTTSMN1; SMN2MAPK1MAPT | |
| SCHEMBL5793348 | 0.76 | MAPT (0.48) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL5793764 | 0.76 | MAPT (0.46) | ALDH1A1SMN1; SMN2MAPK1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006015279-A1 | HETEROCYCLIC DIAMINE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR USEFUL FOR THE TREATMENT OF OBESITY, DIABETES, EATING AND SEXUAL DISORDERS | NEUROGEN CORPORATION (US) | 2006-02-09 | — | — | WO | claimed |