Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | RORC | P51449 | 2/20 | 0.48 |
| ▸ | PGR | P06401 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RORA | P35398 | 1/20 | 0.41 |
| ▸ | RORB | Q92753 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163862 | 0.91 | KDM4E (0.64) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL13067443 | 0.86 | ALDH1A1 (0.54) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL1611235 | 0.86 | KDM4E (0.52) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL4849333 | 0.83 | KDM4E (0.67) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL25620763 | 0.83 | KDM4E (0.53) | KDM4EHPGDALDH1A1HSD17B10MAPK1 | |
| SCHEMBL5798005 | 0.82 | PTGER4 (0.57) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL5797737 | 0.82 | KDM4E (0.54) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL541218 | 0.80 | PTGER4 (0.59) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL20315356 | 0.80 | KDM4E (0.48) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL21093609 | 0.79 | KDM4E (0.46) | KDM4EHPGDALDH1A1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006012310-A2 | CARBAZOLE DERIVATIVES FOR TREATING POLYCYSTIC KIDNEY DISEASE | GENZYME CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |