Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | RORC | P51449 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CRY2 | Q49AN0 | 9/20 | 0.44 |
| ▸ | PER2 | O15055 | 8/20 | 0.44 |
| ▸ | CRY1 | Q16526 | 7/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163862 | 0.90 | KDM4E (0.64) | KDM4EHPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL8134208 | 0.86 | KDM4E (0.57) | KDM4EHPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL5794680 | 0.82 | KDM4E (0.55) | KDM4EHPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL4849333 | 0.82 | KDM4E (0.67) | KDM4EHPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL5798005 | 0.81 | PTGER4 (0.57) | KDM4EHPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL541218 | 0.78 | PTGER4 (0.59) | KDM4EHPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL20631884 | 0.78 | KDM4E (0.50) | KDM4EHPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL29643189 | 0.78 | MAPT (0.65) | KDM4EHPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL15868578 | 0.78 | MAPT (0.65) | KDM4EHPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL7974817 | 0.75 | MAPT (0.68) | KDM4EHPGDALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006030124-A1 | CONDENSED PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND THERAPEUTIC USE OF SAME | SANOFI-AVENTIS (FR) | 2006-03-23 | — | — | WO | disclosed |
| WO-2006012310-A2 | CARBAZOLE DERIVATIVES FOR TREATING POLYCYSTIC KIDNEY DISEASE | GENZYME CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |