Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8270738 | 0.90 | CTSK (0.33) | CTSKFGFR4 | |
| SCHEMBL5791444 | 0.85 | CTSK (0.40) | CTSKFGFR4HCRTR1HCRTR2 | |
| SCHEMBL5793393 | 0.84 | CTSK (0.41) | CTSKFGFR4HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL5792575 | 0.81 | CTSK (0.44) | CTSKFGFR4HCRTR1HCRTR2 | |
| SCHEMBL8270028 | 0.78 | GPR119 (0.37) | CTSKFGFR4HCRTR1HCRTR2 | |
| SCHEMBL5791906 | 0.77 | MAOB (0.40) | CTSK | |
| SCHEMBL5791897 | 0.76 | MAOB (0.41) | CTSK | |
| SCHEMBL5794364 | 0.76 | GPR119 (0.37) | CTSKFGFR4HCRTR1HCRTR2 | |
| SCHEMBL5792640 | 0.74 | CTSK (0.36) | CTSKFGFR4HCRTR1HCRTR2MAPT | |
| Trifluoroacetic Acid SCHEMBL5791564 | 0.73 | CTSK (0.35) | CTSKFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | claimed |
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |