Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.51 |
| ▸ | ACHE | P22303 | 8/20 | 0.51 |
| ▸ | BCHE | P06276 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9879225 | 0.86 | PTGS2 (0.56) | PTGS2ACHEBCHENPC1RAB9A | |
| SCHEMBL6394314 | 0.86 | PTGS2 (0.57) | PTGS2ACHEBCHENPC1RAB9A | |
| SCHEMBL10535136 | 0.82 | PTGS2 (0.50) | PTGS2ACHEBCHENPC1RAB9A | |
| SCHEMBL28671158 | 0.81 | LMNA (0.54) | PTGS2ACHEBCHENPC1RAB9A | |
| SCHEMBL2235652 | 0.80 | PTGS2 (0.46) | PTGS2ACHEBCHEEPHX1LMNA | |
| SCHEMBL27830263 | 0.80 | MEN1 (0.41) | PTGS2ACHEBCHEUGT2B7LMNA | |
| SCHEMBL5388511 | 0.80 | ACHE (0.53) | PTGS2ACHEBCHEALDH1A1LMNA | |
| SCHEMBL3909367 | 0.78 | PTGS2 (0.47) | PTGS2ACHEBCHENPC1RAB9A | |
| SCHEMBL508188 | 0.77 | PTGS2 (0.50) | PTGS2ACHEBCHENPC1RAB9A | |
| SCHEMBL3906858 | 0.77 | ACHE (0.50) | PTGS2ACHEBCHENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006041921-A2 | PREPARATION AND USES OF RHODANINE DERIVATIVES | AUSPEX PHARMACEUTICALS, INC. (US) | 2006-04-20 | — | — | WO | disclosed |
| CN-1026234-C | Thiazolidinedione derivatives for lowering blood glucose | PFIZER (US) | 1994-10-19 | — | — | CN | disclosed |
| EP-0332332-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5130379-A | Anticholesterol agents and antidiabetic agents | PFIZER INC. (US) | 1992-07-14 | — | — | US | disclosed |
| US-5036079-A | Anticholesterol | PFIZER INC. (US) | 1991-07-30 | — | — | US | disclosed |
| CN-1036572-A | Thiazolidinedione derivatives for lowering blood glucose | PFIZER (US) | 1989-10-25 | — | — | CN | disclosed |
| EP-0332332-A1 | Hypoglycemic thiazolidinedione derivatives | PFIZER INC. (US) | 1989-09-13 | — | — | EP | disclosed |