Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31439827 | 1.00 | BRD4 (0.43) | BRD4DPP4KMT2AAKT1KMO | |
| SCHEMBL27821978 | 0.83 | BRD4 (0.41) | BRD4DPP4KMT2AP2RX7HTR2A | |
| SCHEMBL14960647 | 0.83 | HSD11B1 (0.54) | BRD4DPP4P2RX7HSD11B1PDE10A | |
| SCHEMBL14412224 | 0.82 | BRD4 (0.44) | BRD4DPP4L3MBTL1HTR2AHTR2C | |
| SCHEMBL29755473 | 0.81 | HSD11B1 (0.51) | BRD4HSD11B1PDE10A | |
| SCHEMBL18989145 | 0.81 | HSD11B1 (0.51) | BRD4HSD11B1PDE10A | |
| SCHEMBL31039260 | 0.80 | BRD4 (0.41) | BRD4DPP4KMT2AP2RX7HTR2A | |
| SCHEMBL12277386 | 0.80 | AKT1 (0.40) | BRD4DPP4AKT1KMOMAPK14 | |
| SCHEMBL14960634 | 0.79 | BRD4 (0.53) | BRD4L3MBTL1HTR2AHTR2CHSD11B1 | |
| SCHEMBL15803554 | 0.79 | MAPK14 (0.43) | BRD4DPP4P2RX7MAPK14HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150126502-A1 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARM INC (US) | 2015-05-07 | — | — | US | disclosed |
| US-20130231335-A1 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-8445503-B2 | Inhibitors of polo-like kinase | ELAN PHARMACEUTICALS, INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20110212942-A1 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. | 2011-09-01 | — | — | US | disclosed |
| WO-2006046980-A1 | ORGANIC LIGHT EMITTING MATERIALS AND DEVICES | UNIVERSAL DISPLAY CORPORATION (US) | 2006-05-04 | — | — | WO | disclosed |
| US-20060008670-A1 | Organic light emitting materials and devices | UNIVERSAL DISPLAY CORPORATION | 2006-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212942-A1 | INHIBITORS OF POLO-LIKE KINASE | PLK1, POLK, POLR2E | BRD4 837/4885DPP4 3651/4885KMT2A 1570/4885 |
| US-20060008670-A1 | Organic light emitting materials and devices | PPOX, CLTB, TPMT | BRD4 83/4885DPP4 2359/4885KMT2A 760/4885 |
| US-20130231335-A1 | INHIBITORS OF POLO-LIKE KINASE | POLK, PLK1, POLR2E | BRD4 842/4885DPP4 3698/4885KMT2A 1580/4885 |
| US-20150126502-A1 | INHIBITORS OF POLO-LIKE KINASE | POLK, PLK1, POLR2E | BRD4 842/4885DPP4 3698/4885KMT2A 1580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.