Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5795729 | 0.80 | CTNNB1 (0.47) | CTNNB1WNT3ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL5798675 | 0.79 | CYP1A2 (0.43) | AKR1B1ALDH1A1CTNNB1WNT3APOLB | |
| SCHEMBL4245618 | 0.74 | RAB9A (0.51) | AKR1B1CES2ALDH1A1CTNNB1WNT3A | |
| SCHEMBL6970291 | 0.73 | CES2 (0.61) | CES2ALDH1A1CTNNB1WNT3APOLB | |
| SCHEMBL5799397 | 0.73 | PIM1 (0.45) | NTRK1RETPDGFRBCDK8NTRK3 | |
| SCHEMBL5798526 | 0.72 | AKR1B1 (0.48) | AKR1B1JAK2NTRK1RETPDGFRB | |
| SCHEMBL6133926 | 0.72 | NPSR1 (0.44) | AKR1B1CES2ALDH1A1CTNNB1WNT3A | |
| SCHEMBL30758861 | 0.72 | CES2 (0.69) | CES2ALDH1A1CTNNB1WNT3APOLB | |
| SCHEMBL423798 | 0.72 | DDR1 (0.59) | CES2CTNNB1WNT3ALMNASRD5A2 | |
| SCHEMBL28861864 | 0.72 | PTGS1 (0.45) | CES2ALDH1A1CTNNB1WNT3APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |