Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29074432 | 0.82 | NPC1 (0.56) | NPC1RAB9APTPN7DUSP3KMT2A | |
| SCHEMBL5797631 | 0.78 | RAB9A (0.42) | NPC1RAB9AKMT2APOLBL3MBTL1 | |
| SCHEMBL5797683 | 0.78 | NPC1 (0.42) | NPC1RAB9AKMT2APOLBL3MBTL1 | |
| SCHEMBL2264130 | 0.74 | TGM2 (0.50) | NPC1RAB9AKMT2APOLBL3MBTL1 | |
| SCHEMBL5797358 | 0.74 | KMT2A (0.50) | NPC1RAB9AKMT2ALMNAALOX12 | |
| SCHEMBL17429675 | 0.72 | SMN1; SMN2 (0.37) | NPC1RAB9AKMT2AL3MBTL1GAA | |
| SCHEMBL1588133 | 0.71 | NPC1 (0.38) | NPC1RAB9AKMT2AL3MBTL1GAA | |
| SCHEMBL29386482 | 0.71 | NPC1 (0.38) | NPC1RAB9AKMT2AL3MBTL1GAA | |
| SCHEMBL10817318 | 0.71 | AMY1A (0.42) | NPC1RAB9AKMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL29257728 | 0.70 | SMN1; SMN2 (0.58) | NPC1RAB9AKMT2APOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006037468-A1 | HIV REVERSE TRANSCRIPTASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2006-04-13 | — | — | WO | claimed |