Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9806322 | 0.80 | NPSR1 (0.39) | NPSR1KMT2AMEN1CYP2D6TAAR1 | |
| SCHEMBL28905 | 0.79 | KDM1A (0.31) | — | |
| SCHEMBL15229060 | 0.78 | NPSR1 (0.38) | NPSR1KMT2AMEN1CYP2D6TAAR1 | |
| SCHEMBL29420224 | 0.78 | NPSR1 (0.38) | NPSR1KMT2AMEN1CYP2D6TAAR1 | |
| SCHEMBL4653936 | 0.78 | NPSR1 (0.38) | NPSR1KMT2AMEN1CYP2D6TAAR1 | |
| SCHEMBL18549792 | 0.75 | — | — | |
| SCHEMBL8641835 | 0.73 | TRPA1 (0.37) | NPSR1KMT2AMEN1CYP2D6GAA | |
| SCHEMBL10362582 | 0.73 | NPSR1 (0.50) | NPSR1KMT2AMEN1CYP2D6GAA | |
| SCHEMBL306894 | 0.72 | — | — | |
| SCHEMBL10673152 | 0.71 | CYP2D6 (0.42) | TYRKMT2AMEN1CYP2D6GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115748-B2 | Method of making imidazole-2-thiones | ALLERGAN, INC. (US) | 2006-10-03 | — | — | US | claimed |
| WO-2006062890-A1 | METHOD OF MAKING IMIDAZOLE-2-THIONES | ALLERGAN, INC. (US) | 2006-06-15 | — | — | WO | claimed |
| US-20060122400-A1 | Method of making imidazole-2-thiones | ALLERGAN, INC. | 2006-06-08 | — | — | US | claimed |
| US-10858298-B2 | Preparation of diphenyl compounds | EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) | 2020-12-08 | — | — | US | disclosed |
| US-20190315665-A1 | PREPARATION OF DIPHENYL COMPOUNDS | EXXONMOBIL RES & ENG CO (US) | 2019-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315665-A1 | PREPARATION OF DIPHENYL COMPOUNDS | DDT, PCBP1, BMI1 | NPSR1 4730/4885TYR 1363/4885KMT2A 212/4885 |
| US-10858298-B2 | Preparation of diphenyl compounds | DDT, PCBP1, BMI1 | NPSR1 4730/4885TYR 1363/4885KMT2A 212/4885 |
| US-20060122400-A1 | Method of making imidazole-2-thiones | TST, INMT, TPMT | NPSR1 4116/4885TYR 95/4885KMT2A 652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.