Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.65 |
| ▸ | MAOA | P21397 | 2/20 | 0.57 |
| ▸ | ACHE | P22303 | 4/20 | 0.52 |
| ▸ | BCHE | P06276 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425703 | 0.95 | XDH (0.60) | XDHMAOAACHEBCHEMAPT | |
| SCHEMBL7381861 | 0.95 | XDH (0.60) | XDHMAOAACHEBCHEMAPT | |
| SCHEMBL5748445 | 0.94 | MAOA (0.58) | XDHMAOAACHEBCHEMAPT | |
| SCHEMBL5746390 | 0.91 | MAOA (0.56) | XDHMAOAACHEBCHEHTR1D | |
| SCHEMBL5748254 | 0.90 | XDH (0.57) | XDHACHEBCHEHTR1DHTR1B | |
| SCHEMBL5749134 | 0.87 | MAOA (0.59) | XDHMAOAACHEBCHEHTR1B | |
| SCHEMBL7229906 | 0.87 | XDH (0.52) | XDHMAOAACHEBCHEMAPT | |
| SCHEMBL5747126 | 0.85 | MAOA (0.57) | XDHMAOAACHEBCHEHTR1D | |
| SCHEMBL7229666 | 0.84 | XDH (0.48) | XDHMAOAACHEBCHEMAPT | |
| SCHEMBL28198664 | 0.84 | MAOA (0.62) | XDHMAOAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | disclosed |