Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.54 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996901 | 0.86 | ALDH1A1 (0.56) | ALDH1A1MAPTSMN1; SMN2LMNAHPGD | |
| SCHEMBL13099833 | 0.86 | KDM4E (0.65) | ALDH1A1MAPTSMN1; SMN2LMNAHPGD | |
| SCHEMBL30581469 | 0.86 | KDM4E (0.65) | ALDH1A1MAPTSMN1; SMN2LMNAHPGD | |
| SCHEMBL216351 | 0.85 | ALDH1A1 (0.55) | ALDH1A1MAPTSMN1; SMN2LMNAHPGD | |
| SCHEMBL22326014 | 0.83 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2NPSR1RAB9A | |
| SCHEMBL907922 | 0.83 | ALDH1A1 (0.57) | ALDH1A1MAPTSMN1; SMN2LMNARAB9A | |
| SCHEMBL3598134 | 0.82 | ALDH1A1 (0.50) | ALDH1A1MAPTSMN1; SMN2LMNAHPGD | |
| SCHEMBL5417319 | 0.82 | KMT2A (0.55) | ALDH1A1MAPTSMN1; SMN2LMNAHPGD | |
| SCHEMBL2418253 | 0.82 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2LMNAHPGD | |
| SCHEMBL7447406 | 0.79 | MAPK1 (0.54) | ALDH1A1MAPTSMN1; SMN2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006058338-A2 | 4 - PIPERIDINECARBOXAMIDE DERIVATIVES AS MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | WO | disclosed |
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | VDAC1, TRPV1, HVCN1 | ALDH1A1 1117/4885MAPT 4590/4885SMN1; SMN2 4223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.