Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | MASP2 | O00187 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.50 |
| ▸ | NSD2 | O96028 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1872555 | 1.00 | ALDH1A1 (0.60) | ALDH1A1KDM4ENPC1RAB9ANPSR1 | |
| SCHEMBL30634854 | 0.75 | NPC1 (1.00) | ALDH1A1KDM4ENPC1RAB9ANPSR1 | |
| SCHEMBL30561047 | 0.75 | NPC1 (1.00) | ALDH1A1KDM4ENPC1RAB9ANPSR1 | |
| SCHEMBL172216 | 0.75 | NPC1 (1.00) | ALDH1A1KDM4ENPC1RAB9ANPSR1 | |
| SCHEMBL29034384 | 0.73 | ALDH1A1 (0.62) | ALDH1A1KDM4ENPC1RAB9ANPSR1 | |
| Water SCHEMBL9817804 | 0.73 | NPC1 (0.95) | ALDH1A1KDM4ENPC1RAB9ANPSR1 | |
| SCHEMBL2706718 | 0.71 | ALDH1A1 (0.60) | ALDH1A1KDM4ENPC1RAB9ANPSR1 | |
| SCHEMBL277761 | 0.71 | ALDH1A1 (0.60) | ALDH1A1KDM4ENPC1RAB9ANPSR1 | |
| SCHEMBL460600 | 0.71 | ALDH1A1 (0.61) | ALDH1A1KDM4ENPC1RAB9ANPSR1 | |
| SCHEMBL2589250 | 0.71 | ALDH1A1 (0.60) | ALDH1A1KDM4ENPC1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1450 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110655526-A | Cephalosporin-siderophore conjugates and methods of preparation and use thereof | 中国科学院上海药物研究所 | 2020-01-07 | — | — | CN | claimed |
| US-10000450-B2 | N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2018-06-19 | — | — | US | claimed |
| US-20170166524-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-06-15 | — | — | US | claimed |
| US-9611214-B2 | N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-04-04 | — | — | US | claimed |
| US-20140288065-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-09-25 | — | — | US | claimed |
| US-8815871-B2 | N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | claimed |
| US-20130203750-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-08-08 | — | — | US | claimed |
| US-20120065162-A1 | N-N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-03-15 | — | — | US | claimed |
| EP-2303283-A2 | ANTI-CANCER COMBINATION THERAPY | Katholieke Universiteit Leuven K.U. Leuven R&D (BE) | 2011-04-06 | — | — | EP | claimed |
| US-20110065663-A1 | ANTI-CANCER COMBINATION THERAPY | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D | 2011-03-17 | — | — | US | claimed |
| US-4410522-A | BACTERICIDES | TOYAMA CHEMICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | claimed |
| US-4393060-A | ANTICANCER | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1983-07-12 | — | — | US | claimed |
| US-4385169-A | Reactive alpha amino acid polymer | TEIJIN LIMITED (JP) | 1983-05-24 | — | — | US | claimed |
| EP-0029202-B1 | NOVEL TETRAZOLE-5-THIOL ESTERS AND PROCESS FOR PREPARING CEFAMANDOLE USING SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1983-04-13 | — | — | EP | claimed |
| EP-0047014-A2 | Novel thioesters and process for the preparation of the same | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1982-03-10 | — | — | EP | claimed |
| EP-0040506-A2 | Reactive polymer and process for the preparation thereof | TEIJIN LIMITED (JP) | 1981-11-25 | — | — | EP | claimed |
| EP-0029202-A1 | Novel tetrazole-5-thiol esters and process for preparing cefamandole using same | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1981-05-27 | — | — | EP | claimed |
| US-4200744-A | Substituted 7α-methoxy-7β[(2,3-dioxo-1-piperazinyl)carbonylaminophenylacetamido]cephalosporins | TOYAMA CHEMICAL COMPANY, LIMITED (JP) | 1980-04-29 | — | — | US | claimed |
| US-4039536-A | 7-(α-SUBSTITUTED GLYCINAMIDO)-3-SUBSTITUTED METHYL-3-CEPHEM-4-CARBOXYLIC ACIDS AND THEIR DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JA) | 1977-08-02 | — | — | US | claimed |
| US-3930866-A | MAGENTA | FUJI PHOTO FILM CO., LTD. (JA) | 1976-01-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203750-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | SLC6A2, TPH1, SLC6A3 | ALDH1A1 345/4885KDM4E 1194/4885NPC1 701/4885 |
| US-10000450-B2 | N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors | SLC6A2, TPH1, SLC6A3 | ALDH1A1 345/4885KDM4E 1194/4885NPC1 701/4885 |
| US-20110065663-A1 | ANTI-CANCER COMBINATION THERAPY | TYMP, MTAP, NTPCR | ALDH1A1 1909/4885KDM4E 1040/4885NPC1 4079/4885 |
| US-20170166524-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | SLC6A2, TPH1, SLC6A3 | ALDH1A1 345/4885KDM4E 1194/4885NPC1 701/4885 |
| US-20120065162-A1 | N-N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | SLC6A2, TPH1, SLC6A3 | ALDH1A1 380/4885KDM4E 1189/4885NPC1 669/4885 |
| US-20140288065-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | SLC6A2, TPH1, SLC6A3 | ALDH1A1 345/4885KDM4E 1194/4885NPC1 701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.