Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6417145 | 0.76 | ALDH1A1 (0.39) | ALDH1A1TSHRLMNAHTTTDP1 | |
| SCHEMBL11560187 | 0.74 | ALDH1A1 (0.46) | KEAP1NFE2L2RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL12419483 | 0.72 | ESR1 (0.44) | TSHRTDP1CES2CES1 | |
| SCHEMBL374605 | 0.71 | MTNR1A (0.53) | RAB9AALDH1A1SMN1; SMN2TSHRLMNA | |
| SCHEMBL125310 | 0.71 | ALDH1A1 (0.46) | ALDH1A1TSHRKDM4ETDP1 | |
| SCHEMBL11318899 | 0.71 | KEAP1 (0.41) | KEAP1NFE2L2RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL3105534 | 0.70 | MTNR1A (0.52) | RAB9AALDH1A1SMN1; SMN2TSHRLMNA | |
| SCHEMBL16573331 | 0.69 | KEAP1 (0.40) | KEAP1NFE2L2RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL9632432 | 0.69 | KEAP1 (0.51) | KEAP1NFE2L2RAB9ASMN1; SMN2TSHR | |
| SCHEMBL9461590 | 0.68 | ALDH1A1 (0.48) | KEAP1NFE2L2RAB9AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641762-A2 | CCK-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005005393-A2 | CCK-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-01-20 | — | — | WO | disclosed |