Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.53 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.53 |
| ▸ | TTK | P33981 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 5/20 | 0.45 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377202 | 0.86 | MAP2K4 (0.51) | MAP2K4MAPK1MAPKAPK3MAPK6TTK | |
| SCHEMBL8553350 | 0.76 | SLC6A4 (0.51) | KDM4EALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20140840 | 0.70 | OPRM1 (0.50) | MAPK1SLC6A2SLC6A4SLC6A3HTR2C | |
| SCHEMBL22801827 | 0.70 | MAP2K4 (1.00) | MAP2K4MAPK1MAPKAPK3MAPK6TTK | |
| SCHEMBL18977088 | 0.69 | TTK (0.75) | MAP2K4MAPK1MAPKAPK3MAPK6TTK | |
| SCHEMBL19597646 | 0.68 | TTK (0.72) | MAP2K4MAPK1MAPKAPK3MAPK6TTK | |
| SCHEMBL4388788 | 0.68 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30768403 | 0.67 | ALDH1A1 (1.00) | MAP2K4MAPK1MAPKAPK3MAPK6TTK | |
| SCHEMBL855531 | 0.67 | ALDH1A1 (1.00) | MAP2K4MAPK1MAPKAPK3MAPK6TTK | |
| SCHEMBL29640072 | 0.67 | MAP2K4 (0.76) | MAP2K4MAPK1MAPKAPK3MAPK6TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618093-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | Signal Pharmaceuticals LLC (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004094388-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-11-04 | — | — | WO | disclosed |